Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells

T. R. Narasimhan; N. Harindranath; S. Premlata; B. S. Kesava Murthy; P. V. Subba Rao

doi:10.1055/s-2007-969454

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Planta Med 1985; 51(3): 194-197
DOI: 10.1055/s-2007-969454

Research Articles

Toxicity of the Sesquiterpene Lactone Parthenin to Cultured Bovine Kidney Cells

T. R. Narasimhan² , N. Harindranath¹ , S. Premlata² , B. S. Kesava Murthy² , P. V. Subba Rao¹

¹Allergy and Applied Immunology Laboratory, Department of Biochemistry, Indian Institute of Science, Bangalore-560 012, India
²Institute for Animal Health and Veterinary Biologicals, Hebbal, Bangalore-560 024, India

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Publication History

1984

1985

Publication Date:
26 February 2007 (online)

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Abstract

The cytotoxic effect of the sesquiterpene lactone, parthenin was studied in vitro using cultured bovine kidney cells. The drug inhibited macromolecular synthesis. Fifty percent inhibitions in RNA, DNA and protein synthesis were observed when the cells were treated with parthenin at a final concentration of 1 µg/ml. The cytotoxic effect of parthenin was also evident by its ability to markedly inhibit the activities of key cellular enzymes after treatment of the cells with the toxin for 24 h.