Abstract
The biotransformation of 10-hydroxygeraniol and several closely related compounds
by a cell suspension culture of Catharanthus roseus, employing a variety of protocols, was studied. The major products obtained from
10-hydroxygeraniol were: 10-hydroxylinalool, 10-hydroxy-citronellol, 7,8-dihydro-10-hydroxygeraniol,
dihydrocitronellol, and 7,8-dihydro-10-hydroxylinalool. The relative proportions of
products was dependent on the protocol used. Biotransformation of C-1 dideuterated
10-hydroxygeraniol led to the production of reduced products which were mono-deuterated.
Biotransformation of 8-hydroxy-7,8-dihydrogeraniol afforded (-)-8-hydroxy-7,8-dihydrocitronellol
while (+)-10-hydroxycitronellol was reduced to afford a mixture of diastereomers.
