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DOI: 10.1055/s-2007-969395
© Georg Thieme Verlag Stuttgart · New York
Antihepatotoxic Actions of Ginsenosides from Panax ginseng Roots1
1 Part 18 in the Tohoku University series on Liver-protective drugs, and Part 73 on the validity of the Oriental medicinesPublication History
1984
1984
Publication Date:
26 February 2007 (online)
Abstract
The antihepatotoxic effects of ginsenosides, saponins from Panax ginseng, and their aglycones were investigated utilizing carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Prominent protective actions were found with 20(S)-ginsenoside-Rh2, 20(R)-ginsenoside-Rg3 and prosapogenin of ginsenoside-Ro, 20(R)- and 20(S)-ginsenoside-Rs in CCl4-produced cytotoxicity, and 20(S)-ginsenoside-Rh1 and prosapogenin of 20(S)-ginsenoside-Rs were effective in preventing GalN-induced liver cell damage. The antihepatotoxic effects of chikusetsusaponins, saponins of Panax japonicus, were also examined. The structure-activity relationship is discussed.