Antihepatotoxic Actions of Ginsenosides from Panax ginseng Roots1

Hiroshi Hikino; Yoshinobu Kiso; Junko Kinouchi; Shuichi Sanada; Junzo Shoji

doi:10.1055/s-2007-969395

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Planta Med 1985; 51(1): 62-64
DOI: 10.1055/s-2007-969395

Reports

Antihepatotoxic Actions of Ginsenosides from Panax ginseng Roots¹

Hiroshi Hikino² , Yoshinobu Kiso² , Junko Kinouchi³ , Shuichi Sanada³ , Junzo Shoji³

²Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan
³School of Pharmaceutical Sciences, Showa University, Hatanodai, Shinagawa-ku, Tokyo, Japan

1 Part 18 in the Tohoku University series on Liver-protective drugs, and Part 73 on the validity of the Oriental medicines

Further Information

Publication History

1984

1984

Publication Date:
26 February 2007 (online)

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Abstract

The antihepatotoxic effects of ginsenosides, saponins from Panax ginseng, and their aglycones were investigated utilizing carbon tetrachloride (CCl₄)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Prominent protective actions were found with 20(S)-ginsenoside-Rh₂, 20(R)-ginsenoside-Rg₃ and prosapogenin of ginsenoside-Ro, 20(R)- and 20(S)-ginsenoside-Rs in CCl₄-produced cytotoxicity, and 20(S)-ginsenoside-Rh₁ and prosapogenin of 20(S)-ginsenoside-Rs were effective in preventing GalN-induced liver cell damage. The antihepatotoxic effects of chikusetsusaponins, saponins of Panax japonicus, were also examined. The structure-activity relationship is discussed.

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