Isolation of (-)-Epicatechin from Pterocarpus marsupium and its Pharmacological Actions

Abstract

(-)-Epicatechin has been isolated from the bark of Pterocarpus marsupium Roxb (Leguminosae). This flavonoid compound was tested for its activity on central nervous system, isolated frog heart preparations and blood sugar levels of rats. Preliminary acute toxicity studies were also carried out. It was observed that (-)-epicatechin did not have any effect on central nervous system of rats and mice, (-)-epicatechin had shown both positive chronotropic and inotropic effects on frog hearts, the effect of which is blocked by propranolol. The compound in higher doses caused hyperglycemia in rats and this effect is also blocked by propranolol, showing adrenergic type of activity. (-)-Epicatechin was found to have no untoward effect even in higher doses.