Planta Med 1985; 51(1): 28-31
DOI: 10.1055/s-2007-969384
Research Articles

© Georg Thieme Verlag Stuttgart · New York

Central Nervous Depressant Activity of Valerenic Acid in the Mouse

H. Hendriks1 , R. Bos1 , H. J. Woerdenbag1 , A. Sj. Koster2
  • 1Laboratory of Pharmacognosy, State University of Groningen, Ant. Deusinglaan 2, 9713 AW Groningen, The Netherlands
  • 2Department of Pharmacology, Faculty of Pharmacy, State University Utrecht, Catharijnesingel 60, 3511 GH Utrecht, The Netherlands
Further Information

Publication History



Publication Date:
26 February 2007 (online)


Valerenic acid, isolated from Valeriana officinalis L. s.l. affected the rotarod and traction performance of mice in a similar manner to that of pentobarbital which was used together with chlorpromazine and diazcpam as reference substance in both tests. A decrease of locomotility of mice was also noticed after administration of valerenic acid, in particular when this compound was administered to the same group of mice a week later than the vehicle. In addition valerenic acid was found to prolong the pentobarbital induced sleeping time. It can be concluded, that valerenic acid has aspecific central nervous depressent properties. This factor should be taken into account when considering the sedative action of Valerian preparations.