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Planta Med 1986; 52(5): 370-374
DOI: 10.1055/s-2007-969188
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© Georg Thieme Verlag Stuttgart · New York

Coumestans as the Main Active Principles of the Liver Drugs Eclipta alba and Wedelia calendulacea 1

Hildebert Wagner2 , Bettina Geyer2 , Yoshinobu Kiso3 , Hiroshi Hikino3 , Govind S. Rao4
  • 2Institut für Pharmazeutische Biologie der Universität München, Karlstr. 29, D-8000 München 2, Federal Republic of Germany.
  • 3Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai, Japan.
  • 4Institut für Klinische Biochemie der Universität Bonn, Sigmund-Freud-Str. 25, D-5300 Bonn-Venusberg, Federal Republic of Germany.
1 Part 13 in the University of Munich series on “drugs for liver therapy” (H. Wagner), Part 31 in the Tohoku University series on liver-protective drugs (H. Hikino).
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1986

Publikationsdatum:
26. Februar 2007 (online)

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Abstract

From the ethyl acetate-soluble fraction of the drug Eclipta alba (L.) Hassk. Asteraceae, besides a flavonoid and simple phenolcarboxylic acids, the coumestans wedelolactone and demethyl-wedelolactone were isolated as the main active principles. Both constituents exhibited antihepatotoxic activity in assays employing CCl4-, GalN-, and phalloidin-cytotoxicity in rat hepatocytes. They also showed a significant stimulatory effect on liver cell regeneration. A HPLC-method is described for qualitative and quantitative analysis of the coumestans, in the extracts of Eclipta alba and also Wedelia calendulacea Less., Asteraceae.