Planta Med 1986; 52(4): 275-278
DOI: 10.1055/s-2007-969151
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© Georg Thieme Verlag Stuttgart · New York

Antitussive Effects of L-Ephedrine, Amygdalin, and Makyokansekito (Chinese Traditional Medicine) using a Cough Model Induced by Sulfur Dioxide Gas in Mice

Masanori Miyagoshi, Sakae Amagaya, Yukio Ogihara
  • Faculty of Pharmaceutical Sciences, Nagoya City University, 3-1, Tanabe-dori, Mizuho-ku, Nagoya 467, Japan
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Publication History

1986

Publication Date:
26 February 2007 (online)

Abstract

A cough model induced by sulfur dioxide gas was devised for use with mice. In this method, the ED50 of morphine hydrochloride was 1.58 mg/kg p. o. and that of codeine phosphate was 10.28 mg/kg p. o. Using the method established, L-ephedrine hydrochloride, 0.4, 4.0 and 40 mg/kg p. o., inhibited the cough induction in a dose-dependent manner and amygdalin, 1.0, 10 and 100 mg/kg p. o., also inhibited the cough induction. On the other hand, treatment of Makyokansekito, 162 mg/kg p. o., which contained Ephedrae herba (L-ephedrine, 4.6 mg/kg) and Armeniacae semen (amygdalin, 8.4 mg/kg) as component, showed stronger antitussive effects than the individual crude drugs.

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