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Planta Med 1986; 52(3): 163-168
DOI: 10.1055/s-2007-969111
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© Georg Thieme Verlag Stuttgart · New York

Antihepatotoxic Actions of Allium sativum Bulbs1

Hiroshi Hikino2 , Masahiro Tohkin2 , Yoshinobu Kiso2 , Tsuneo Namiki3 , Shoji Nishimura4 , Kimori Takeyama4
  • 2Pharmaceutical Institute, Tohoku University, Aoba-yama, Sendai 980, Japan.
  • 3Department of Pathology, National Hospital of Sendai, 2-8-8 Miyagino, Sendai, Japan.
  • 4Research Laboratory, Riken Chemical Industries Ltd., 48 Fukakusa-Mukaigawara-cho, Fushimi-ku, Kyoto, Japan.
1 Part 29 in Liver-protective drugs. Also Part 108 in the series on the validity of the Oriental medicines.
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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

Garlic constituents, the volatile oil, alliin, S-allylmercaptocysteine (ASSC) and S-methylmercapto-cysteine (MSSC) were subjected to assay for their antihepatotoxic activity using the in vitro and in vivo liver damage models. Marked inhibitory activity was found with the volatile oil, ASSC and MSSC in carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes as model systems. ASSC exhibited a remarkable inhibitory action and the volatile oil, alliin and MSSC showed tendencies to elicit protective actions in GalN-produced liver lesion in rats. The volatile oil inhibited CCl4-induced free radical formation and lipid peroxidation, indicating that anti-oxidative activity participates in the inhibitory effect of the volatile oil in CCl4-evoked liver damage.

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