A Neuropsychopharmacological Study of Syzygium cuminii

Abstract

Neuropsychopharmacological studies have been conducted on the chloroform fraction extracted from the seeds of Syzygium cuminii L., on experimental animals. The extract was found to produce alteration in general behaviour pattern, reduction in spontaneous motility, hypothermia, potentiation of pentobaritone hypnosis, analgesia, reduction in exploratory behavoiur pattern, muscle relaxant action, and suppression of aggressive behavoiur. The extract also caused suppression of conditioned avoidance response and showed antagonism to amphetamine group toxicity. These observations suggest that the extract of the seeds of S. cuminii possesses a potent CNS depressant action.