Prevention of Dental Caries by Oriental Folk Medicines - Active Principles of Zizyphi Fructus for Inhibition of Insoluble Glucan Formation by Cariogenic Bacterium Streptococcus mutans

H. Kohda; K. Kozai; N. Nagasaka; Y. Miyake; H. Suginaka; K. Hidaka; K. Yamasaki

doi:10.1055/s-2007-969095

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Planta Med 1986; 52(2): 119-120
DOI: 10.1055/s-2007-969095

Full Papers

Prevention of Dental Caries by Oriental Folk Medicines - Active Principles of Zizyphi Fructus for Inhibition of Insoluble Glucan Formation by Cariogenic Bacterium Streptococcus mutans

H. Kohda¹ , K. Kozai² , N. Nagasaka² , Y. Miyake³ , H. Suginaka³ , K. Hidaka¹ , K. Yamasaki¹

¹Institute of Pharmaceutical Sciences, School of Medicine, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734, Japan
²Department of Pedodontics, School of Dentistry, Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734, Japan
³Department of Microbiology and Oral Bacteriology, School of Dentistry Hiroshima University, 1-2-3, Kasumi, Minami-ku, Hiroshima 734, Japan

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Publication History

1985

Publication Date:
26 February 2007 (online)

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Abstract

The chloroform extract of Zizyphi Fructus had inhibitory activity against insoluble glucan formation by glucosyltransferase from the cariogenic bacterium Streptococcus mutans. The active substances were isolated from the plant and the chemical structures were elucidated to be oleanolic acid and ursolic acid.