Planta Med 1986; 52(1): 61-63
DOI: 10.1055/s-2007-969072

© Georg Thieme Verlag Stuttgart · New York

Pharmacological Studies on Leaves of Withania somnifera

S. Sudhir1 , R. D. Budhiraja2 , G. P. Miglani2 , B. Arora2 , L. C. Gupta2 , K. N. Garg2
  • 14/8 FM, Medical College, Rohtak-124001 (Haryana), India
  • 2Department of Pharmacology and Pathology, Rohtak-124001, Haryana, India
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Publication History


Publication Date:
26 February 2007 (online)


Anti-inflammatory activity and protective effect against CCl4-induced hepatotoxicity of alcoholic extract of leaves of Withania somnifera have been assessed. The leaves were found to possess marked effects in subacute inflammation and hepatotoxicity. A comparison of the anti-inflammatory properties revealed the extract at 1 g/kg dose to be as active as 50 mg/kg of phenylbutazone and 10 mg/kg of hydrocortisone. The protective effect of the extract at 1 g/kg dose against CCl4-induced hepatotoxicity was comparable to 10 mg/kg of hydrocortisone.