Synthesis of Pyrazoloquinolizinones via a Three-Component Reaction

V. A. Chebanov; V. E. Saraev; S. M. Desenko; V. N. Chernenko; S. V. Shishkina; O. V. Shishkin; K. M. Kobzar; C. O. Kappe

doi:10.1055/s-2007-968690

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Synfacts 2007(7): 0683-0683
DOI: 10.1055/s-2007-968690

Synthesis of Heterocycles

Synthesis of Pyrazoloquinolizinones via a Three-Component Reaction

Contributor(s): Victor Snieckus, Yigang Zhao
V. A. Chebanov*, V. E. Saraev, S. M. Desenko, V. N. Chernenko, S. V. Shishkina, O. V. Shishkin, K. M. Kobzar, C. O. Kappe
‘Institute for Single Crystals’ of the National Academy of Sciences of Ukraine, Kharkiv, Ukraine; Karl-Franzens-Universität Graz, Austria; Technische Universität München, Garching, Germany

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Publikationsdatum:
22. Juni 2007 (online)

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Significance

A microwave-assisted synthesis of pyrazoloquinolizinones by a 3-CR of aminopyrazoles, aldehydes and 1,3-diketones is described. The reaction, carried out under strongly basic conditions directly affords the pyrazoloquinolizinones with the stereogenic centers in trans relationship. The scope of the reaction was insufficiently explored.