Adhatoda vasica - Justicia adhatoda - Alte Arzneipflanze neu entdeckt

Zusammenfassung

Adhatoda vasica (syn. Justicia adhatoda L.) stellt eine alte Arzneipflanze dar, die aufgrund ihrer Chinazolinalkaloide traditionell als Bronchialtherapeutikum verwendet wurde. Obwohl die Blattdroge auf dem indischen Subkontinent ein relativ breites medizinisches Anwendungsgebiet hat und auch als sicheres und lokal herstellbares Arzneimittel seitens der WHO bewertet wird, ist die Droge im europäischen Bereich für die Indikation Erkältungskrankheiten weitgehend in Vergessenheit geraten. Demgegenüber werden nasale Darreichungsformen aus Adhatoda mittlerweile mit der Indikation allergische Rhinitis eingesetzt. Die vorliegende Monographie fasst das bisherige Wissen um Adhatoda vasica zusammen, dies speziell unter Berücksichtigung phytochemischer Aspekte, der pharmakologischen und klinischen Literatur zur medizinischen Anwendung entsprechender Extrakte.

Summary

Adhatoda vasica (syn. Justicia adhatoda L.), is an Indian herbal plant, which due to its quinazolin alkaloids, is traditionally used for treating respiratory diseases. Despite the fact that the herbal drug is still widely used in Indian local medicine and is rated by WHO as safe with local manufacturability, its use in European medicine for the therapy of respiratory diseases has drastically reduced. In contrast, the nasal application of Adhatoda extracts for allergic rhinitis has been increasing on the German market. The following monograph reviews the respective literature on phytochemical, pharmacological and clinical data of Adhatoda vasica.

Adhatoda vasica (syn. Justicia adhatoda L.) - Acanthaceae - Chinazolinalkaloide - Inhaltsstoffe - antibakteriell - antiasthmatisch - antiallergisch - klinische Studien

Adhatoda vasica (syn. Justicia adhatoda L.) - Acanthaceae - quinazolin alkaloids - antiasthmatic - antiallergic - clinical study

Literatur

• 1 Abd F El-Megeed Hashem, Ahmed S Elsawi. Isoquinoline and quinazoline alkaloids from Adhatoda vasica NEES.  Pharm Pharmacol Lett. 1998;  8 167-169
• 2 Ahmed S Elsawi, Abd F El-Megeed Hashem, Ali AM. Flavonoids and antimicrobial volatiles from Adhatoda vasica NEES.  Pharm Pharmacol Lett. 1999;  9 52-56
• 3 Amin AH, Mehta DR. A bronchodilatator alkaloid (vasicinone) from Adhatoda vasica Nees.  Nature Suppl. 1959;  17 1317
• 4 Atal CK. Chemistry and Pharmacology of Vasicine - a new Oxytocic and Abortifacient. Regional Res. Laboratory, Jammu-Tawi 1980
• 5 Bagachi GD, Dwivedi PD, Haider F, Singh S. et al. . Seasonal variation in vasicince content in Adhatoda species grown under north Indian plain condition.  J Med Arom Plant Sci. 2003;  25 37-40
• 6 Bhattacharyya D, Pandit S, Jana U, Sen S, Sur TK. Hepatoprotective activity of Adhatoda vasica aqueous leaf extract on D-galactosamine-induced liver damage in rats.  Fitoterapia. 2005;  76 223-225
• 7 British Pharmaceutical Codex. London: Pharmaceutical Press 1949
• 8 Cambridge GW, Jansen AB, Jarman DA. Bronchodilating action of vasicinone and related compounds.  Nature. 1962;  196 1217
• 9 Chakraborty A, Brantner AH. Study of alkaloids from Adhatoda vasica Nees. On their anti-inflammatory activity.  Phytother Res. 2001;  15 532-534
• 10 Claeson UP, Malmfors T, Wikman G, Bruhn JG. Adhatoda vasica: a critical review of ethnopharmacological and toxicological data.  J Ethnopharmacol. 2000;  72 1-20
• 11 Cos P, Vlietinck AJ, VandenBerghe D, Maes L. Anti-infective potential of natural products: How to develop a stronger in vitro „proof-of-concept”.  J Ethnopharmacol. 2006;  106 290-302
• 12 Dhuley JN. Antitussive effect of Adhatoda casica extract on mechanical or chemical stimulation-induced coughing in animals.  J Ethnopharmacol. 1999;  67 361-365
• 13 Dorsch W, Wagner H. New antiasthamtic drugs of plant origin.  Int Arch Allergy Appl Immunol. 1991;  94 262-265
• 14 Graubaum HJ, Grünwald J. Beurteilung der Wirksamkeit und Verträglichkeit von Klosterfrau Allergin® (Adhatoda vasica) bei der Behandlung der saisonalen allergischen Rhinitis; eine Anwendungsbeobachtung.  Z Phytotherapie. 2005;  26 S25
• 15 Greig WV, Free WL. Ectoparasiticide Formulation, Especially for Control of Headlice. PCT Int. Appl. 2002
• 16 Irshad K, Faheem I, Akram KM. Isolation, purification and structural determination of alkaloids from the flowers of Adhatoda vasica.  J Nat Sci Math. 2004;  44 1-4
• 17 Johri RK, Zuthsi U. Mechanism of action of 6,7,8,9,10,12-hexahydro-azepino-[2,1-b]- quinazolin-12-one (RLX) - a novel bronchodilator.  Indian J Physiol Pharmacol. 2000;  44 75-81
• 18 Joshi BS, Bai Y, Puar MS, Dubose KK, Pelletier SW. J Nat Prod. 1994;  57 953-962
• 19 Kogate CK, D'Cruz JL, Kumar RA, Apte SS. Anti-insect and juvenoidal activity of phytochemicals derived from Adhatoda vasica Nees.  Ind J Nat Prod. 1985;  1 7-9
• 20 Kulkarni SR, Nilapwar SM. Extraction, isolation and pharmacological evaluation of naturally occurring pheophytin A from Adhatoda vasica Nees.  Indian Drugs. 2001;  38 164-169
• 21 Kumar A, Ram J, Samarth RM, Kumar M. Modulatory influence of Adhatoda vasica Nees leef extract against gamma irridation in Swiss albino mice.  Phytomedicine. 2005;  12 285-293
• 22 Kumar S, Gopal K. Screening of plant species for inhibition of bacterial population of raw water.  J Envir Sci Health. 1999;  A34 975-987
• 23 Reynolds JEF, Prasa AD. Martindale 28, The Extra Pharmacopoeia. London: The Pharmaceutical Press 1982: 688
• 24 Müller A, Antus S, Bittinger M, Dorsch W. et al. . Chemistry and pharmacology of the antiasthmatic plants Galphinia glauca, Adhatoda vasica and Picrorhiza kurroa.  Planta Med. 1993;  59 586
• 25 Munro D, Munro J, Bone K. A Head Lice Formulation containing Adhatoda and Stemon. PCT Int. Appl. 2002
• 26 Narimanian M, Badalyan M, Pansyan V, Gabrielyan E. et al. . Randomized trial of a fixed combination (KanJang) of herbal extracts containing Adhatoda vasica, Echinacea purpurea and Eleutherococcus senticosus in patients with upper respiratory tract infections.  Phytomedicine. 2005;  12 539-547
• 27 Nighat S, Muhammad A Aijaz, Yousuf A, Nighat A. Phytochemical studies on Adhatoda vasica.  Pakistan J Scientific Ind Res. 2005;  48 180-183
• 28 Paliwa JK, Dwivedi AK, Singh S, Gutpa RC. Pharmacokinetics and in-situ absorption studies of a new anti-allergic compounds 73/602 in rats.  Int J Pharm. 2000;  197 213-220
• 29 Pandita K, Bhatia MS, Thappa RK, Agarwal SG. et al. . Seasonal variation of alkaloids of Adhatoda vasica and detection of glycosides and N-Oxides of vasicine and vasicinone.  Planta Med. 1983;  48 81-82
• 30 Planchon G, Collin E. Les Drogues Simples d'Origine Végétale. Paris: Octave Doin Editeur 1995: 542
• 31 Qureshi S, Rai MK, Agrawal SC. In vitro evaluation of inhibitory nature of extracts of 18 plant species of Chhindwara against 3-keratinophilic fungi.  Hindustan Antibiot Bull. 1997;  39 56-60
• 32 Ranjan KS, Prasad G, Sinha AH. Evaluation of some bitter plant extracts against aflatoxin production and growth of Aspergillus flavus.  Nat Acad Sci Lett. 1991;  14 241-243
• 33 Rehman A, Nighat S, Farzana A, Iqbal CM. Phytochemical studies on Adhatoda vasica.  Nat Prod Lett. 1997;  10 249-256
• 34 Sharma N, Trivedi PC. Screening of leaf extracts of some plants for their nematicidal and fungicidal properties against Meloidogyne incognita and Fusarium oxysporum. Asian.  J Exp Sci. 2002;  16 21-28
• 35 Singh RP, Padmavathi B, Rao AR. Modulatory influence of Adhatoda vasica (Justicia adhatoda) leaf extract on the enzymes of xenobiotic metabolism, antioxidant status and lipid peroxidation in mice.  Mol Cell Biochem. 2000;  213 99-109
• 36 Singh RS, Misra TN, Pandey HS, Singh BP. Aliphatic hydroxyketones from Adhatoda vasica.  Phytochemistry. 1991;  30 3799-3801
• 37 Singh RS, Misra TN, Pandey HS, Singh BP. A new aliphatic alcohol from Adhatoda vasica.  Fitoterapia. 1992;  63 262-263
• 38 Schneider E. Justicia. In: Hänsel R, Keller K, Rimpler H, Schneider G (Hrsg.): Hagers Handbuch der Pharmazeutischen Praxis, 5. Aufl., Drogen Bd. 5. Berlin, Heidelberg, New York: Springer 1993: 595-602
• 39 Thappa RK, Agarwal SG, Dhar KL, Gupta VK, Goswami KN. Two pyrroloquinazolines from Adhatoda vasica.  Phytochemistry. 1996;  42 1485-1488
• 40 Wakhloo RL, Wakhloo OP, Gupta OP, Atal CK. Vasicince hydrochloride, a new drug for interruption of pregnancy.  J Obsttrics Gyn Ind. 1979;  29 939-940
• 41 World Health Organisation .The Use of Traditional Medicine in Primary Health Care. A Manual for Health Workers in South-East Asia. SEARO Regional Health Papers, 19. New Dehli 1990: 1-2
• 42 Zabeer A, Bhagat A, Gupta OP, Singh GD. et al. .Synthesis and bronchodilator activity of a new quinazolin derivative. Eur J Med Chem 2006