Planta Med 2007; 73(6): 578-584
DOI: 10.1055/s-2007-967187
Natural Product Chemistry
Original Paper
© Georg Thieme Verlag KG Stuttgart · New York

HPLC-SPE-NMR Characterization of Sesquiterpenes in an Antimycobacterial Fraction from Warburgia salutaris

Cailean Clarkson1 , Eliya V. Madikane2 , 3 , Steen Honoré Hansen4 , Peter J. Smith2 , Jerzy W. Jaroszewski1
  • 1Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
  • 2Department of Medicine, University of Cape Town, Cape Town, South Africa
  • 3Department of Pharmacology, University of Oxford, Oxford, United Kingdom
  • 4Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Copenhagen, Denmark
Weitere Informationen

Publikationsverlauf

Received: January 15, 2007 Revised: March 21, 2007

Accepted: March 24, 2007

Publikationsdatum:
07. Mai 2007 (online)

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Abstract

HPLC-SPE-NMR analysis of a chemically complex antimycobacterial fraction of Warburgia salutaris allowed the rapid identification of seven new and four known drimane- and coloratane-type sesquiterpenes. This recently introduced hyphenated technique is therefore a highly valuable tool for elucidation of the chemistry of biologically active fractions of natural origin.

References

Prof. Jerzy W. Jaroszewski

Department of Medicinal Chemistry

Faculty of Pharmaceutical Sciences

University of Copenhagen

Universitetsparken 2

2100 Copenhagen

Denmark

Fax: +45-3530-6040

eMail: jj@farma.ku.dk