Planta Med 2007; 73(3): 236-240
DOI: 10.1055/s-2007-967117
Original Paper
Pharmacology
© Georg Thieme Verlag KG Stuttgart · New York

Monoglycerides and Fatty acids from Ibervillea sonorae Root: Isolation and Hypoglycemic Activity

Erica Hernández-Galicia1 , 2 [*] , Fernando Calzada2 , Rubén Roman-Ramos1 , Francisco J. Alarcón-Aguilar1
  • 1División de Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana, Unidad Iztapalapa, México, D.F.
  • 2Unidad de Investigación Médica en Farmacología de Productos Naturales, Hospital de Pediatría, 2° Piso, Centro Médico Nacional Siglo XXI, IMSS, México D.F., México
Further Information

Publication History

Received: October 17, 2006

Accepted: January 5, 2007

Publication Date:
22 February 2007 (eFirst)

Abstract

Eleven monoglycerides (MG), 1-monopalmitin (1), glyceryl 1-monomargarate (2), 1-monostearin (3), glyceryl 1-monononadecylate (4), glyceryl 1-monoarachidate (5), glyceryl 1-monobehenate (6), glyceryl 1-monotricosanoate (7), glyceryl 1-monotetracosanoate (8), glyceryl 1-monopentacosanoate (9), glyceryl 1-monohexacosanoate (10) and glyceryl 1-monooctacosanoate (11), together with five fatty acids (FA), lauric acid (12), myristic acid (13), pentadecanoic acid (14), palmitic acid (15) and stearic acid (16) were isolated of the root of Ibervillea sonorae Greene (Cucurbitaceae). Their structures were determined by spectroscopic and chemical methods as well as GC-MS analysis. The hypoglycemic activity of the dichloromethane (DCM) extract, of fractions (F1 - F10 and SF1 - SF5), of monoglycerides (MG) and of fatty acids (FA) mixtures obtained of the root from I. sonorae was evaluated in normoglycemic and alloxan-induced diabetic mice. The results showed that by intraperitoneal administration the DCM extract (300 mg/kg), F9 (300 mg/kg) and SF1 (150 mg/kg) significantly reduced glucose levels in both models. For fraction SF1, the hypoglycemic activity was more pronounced than that of tolbutamide (150 mg/kg) used as control. However, neither MG (75 mg/kg) nor FA (75 mg/kg) mixtures isolated from SF1 exhibited a significant hypoglycemic effect. However, when MG and FA were combined in equal proportions (75 mg: 75 mg/kg), their effect was comparable to that of SF1. The observed activity for the DCM extract, F9, SF1 and the MG-FA mixture provides additional support for the popular use of this plant in the treatment of diabetes mellitus in Mexican traditional medicine.