© Georg Thieme Verlag KG Stuttgart · New York
Mucin-secreting neoplastic polyp: a unique endoscopic presentation of early colon cancer
05 July 2007 (online)
A 73-year-old man was referred to our hospital to undergo polypectomy. Colonoscopy showed a protruding polyp, 25 mm in diameter, at the hepatic flexure. ([Figure 1] a). The polyp was reddish and showed characteristic mucin at its apex, suggesting secretion from within the polyp. Magnified chromoendoscopy with 0.4 % indigo carmine dye demonstrated a type IV pit pattern over the entire polyp surface, suggestive of tubulovillous or villous adenoma . The polyp was removed en bloc by endoscopic mucosal resection and, interestingly, a jelly-like substance, similar to the mucin at the polyp apex, was also seen at the resection site ([Figure 1] b). Surprisingly, the polyp was diagnosed histologically as a submucosal deeply invasive cancer arising in a tubulovillous adenoma ([Figure 2]). The invasive cancer consisted mainly of moderately differentiated adenocarcinoma with mucinous carcinoma in part. A cross-sectional view of the polyp showed that the invasive cancer was totally covered by tubulovillous adenoma, making it impossible to diagnose the invasive cancer on the basis of the surface pit pattern  . Interestingly, the mucinous carcinoma was connected to the top and the bottom of the resected lesion, appearing endoscopically as mucinous and jelly-like before and after resection. As the vertical margin was positive for cancer, additional surgical resection was performed with curative intent. No locally residual tumor or lymph node metastasis was detected in the surgically resected specimens.
Figure 1 Colonoscopy showed a protruding polyp, 25 mm in diameter, at the hepatic flexure. a The polyp was reddish and showed characteristic mucin at its apex, suggesting its secretion from within the polyp. b A jelly-like substance, similar to the mucin at the polyp apex, was also seen at the resection site of this polyp.
Figure 2 Histologically, the polyp was diagnosed as a submucosal deeply invasive cancer arising in a tubulovillous adenoma.
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K. Fu, MD
Department of Radiology
Dokkyo University School of Medicine