Stereoselective Synthesis of rac-4′-Ethynyl-2′-deoxy- and 4′-Ethynyl-2′,3′-dideoxy-2′,3′-didehydronucleoside Analogues

Abstract

Synthesis of a racemic 4′-ethynyl-2′-deoxyribose intermediate using stereoselective chelation control is presented. This intermediate is further transformed to 4′-ethynyl-2′-deoxy- and 4′-ethynyl-2′,3′-dideoxy-2′,3′-didehydronucleoside analogues.

HIV - nucleosides - stereoselective synthesis - carbohydrates - chelation control

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