Int J Sports Med 2007; 28(9): 722-726
DOI: 10.1055/s-2007-964891
Physiology & Biochemistry

© Georg Thieme Verlag KG Stuttgart · New York

Effect of Aspirin and Ibuprofen on GI Permeability during Exercise

G. P. Lambert1 , M. Boylan2 , J.-P. Laventure1 , A. Bull1 , S. Lanspa3
  • 1Department of Exercise Science and Athletic Training, Creighton University, Omaha, United States
  • 2Department of Biology, Creighton University, Omaha, United States
  • 3Department of Medicine, Creighton University, Omaha, United States
Further Information

Publication History

accepted after revision September 21, 2006

Publication Date:
13 April 2007 (eFirst)


This study was conducted to determine the effects of aspirin or ibuprofen on gastrointestinal permeability when combined with exercise. Eight runners completed three 60 min treadmill runs at 70 % V·O2max. For 24 hours prior to each run, subjects ingested aspirin (2 × 325 mg), ibuprofen (2 × 200 mg), or placebo capsules every 6 hours. Immediately before each run, a solution containing 5 g sucrose, 5 g lactulose, and 2 g rhamnose was ingested. Urine produced during each run, and for 4 h afterwards was collected. Urinary excretion of sucrose is an indicator of gastroduodenal permeability. The excretion ratio of lactulose-to-rhamnose assesses small intestinal permeability. Sucrose excretion (%) was greater (p < 0.017) for aspirin (0.37 [0.2 - 0.97]) compared to placebo (0.09 [0.05 - 0.30]) or ibuprofen (0.22 [0.1 - 0.39]) and sucrose excretion for ibuprofen was greater than placebo. The lactulose-to-rhamnose ratio was greater for aspirin (0.09 [0.08 - 0.30]) than placebo (0.065 [0.04 - 0.08]) however ibuprofen (0.08 [0.06 - 0.19]) was not different from aspirin or placebo. These results indicate that with prolonged running, gastroduodenal permeability is increased if aspirin or ibuprofen is used prior to such exercise. Furthermore, aspirin promotes greater gastroduodenal permeability and also increases small intestinal permeability.