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DOI: 10.1055/s-2007-963631
© Karl Demeter Verlag im Georg Thieme Verlag KG Stuttgart · New York
Standards und Innovationen in der Diagnostik der gastroösophagealen Refluxkrankheit
Standards and Innovations in the Diagnosis of Gastroesophageal Reflux DiseasePublikationsverlauf
Manuskript eingetroffen: 13.7.2007
Manuskript akzeptiert: 5.10.2007
Publikationsdatum:
19. November 2007 (online)

Zusammenfassung
Die gastroösophageale Refluxkrankheit (GERD) nimmt eine zentrale Rolle in der Patientenversorgung ein. Ein Großteil der Patienten, vor allem in den westlichen Industriestaaten, leidet an Symptomen einer Refluxkrankheit. Der Artikel gibt eine Übersicht über die wichtigsten Verfahren zur Diagnostik der GERD. Standardverfahren wie pH-Metrie, Bilitec und Manometrie, aber auch neue diagnostische Verfahren wie die Impedanzmessung und die Bravo pH-Metrie werden in Funktion und Anwendung beschrieben. Auch endoskopische Standards und neue Verfahren wie Chromo- und Magnifikationsendokopie, narrow band imanging (NBI) und computed virtual chromoendoscopy (CVC) werden dargestellt. Nicht alle, dieser teilweise neuen Verfahren müssen bei jedem Patienten Anwendung finden. Vielmehr erachten wir es für sinnvoll, die Untersuchungsmethoden, deren Vor- und Nachteile, genau zu kennen. Nur so ist es möglich, sie gezielt einzusetzen. Ziel der Untersuchungen ist die Charakterisierung der GERD bei dem jeweiligen Patienten, um eine gezielte Therapie anwenden zu können.
Abstract
Gastroesophageal reflux disease (GERD) is one of the most common gastrointestinal diseases in the world. This article gives an overwiew about diagnostic procedures for GERD. Standard procedures such as pH-metry, Bilitec and manometry and also new diagnostic tools such as combined multichannel intraluminal impedance (MII) and pH-metry and Bravo Capsule are described in detail. Established endoscopy criteria as well as innovative techniques such as magnification, narrow band imaging and computed virtual chromoendoscopy are also presented. Not all of these procedures need to be used in every patient. Therefore, it is important to know the technical aspects, indications, advantages and disadvantages of each method in order to appropriately use any of these tests. The final goal is to characterise GERD and provide the patient with an appropriate therapy.
Schlüsselwörter
GERD - pH-Metrie - Bilitec - Bravo MII-pH - Impedanz - MII-pH - Endoskopie
Key words
GERD - pH-metry - Bilitec - Bravo MII-pH - Impedance - MII-pH - endoscopy
Literatur
- 1
Mönkemüller K, Malfertheiner P.
Is non-erosive reflux disease (NERD) an inflammatory condition?.
CML Gastroenterology.
2006;
25
81-87
Reference Ris Wihthout Link
- 2
Vakil N, Zanten S V, Kahrilas van P. et al .
The Montreal definition and classification of gastroesophageal reflux disease: a global
evidence-based consensus.
Am J Gastroenterol.
2006;
101
1900-1920; quiz 1943
Reference Ris Wihthout Link
- 3
Sifrim D, Blondeau K.
New techniques to evaluate esophageal function.
Dig Dis.
2006;
24
243-251
Reference Ris Wihthout Link
- 4
Fass R.
Distinct phenotypic presentations of gastroesophageal reflux disease: a new view of
the natural history.
Dig Dis.
2004;
22
100-107
Reference Ris Wihthout Link
- 5
Savary M, Miller G.
L’oesophage.
Manuel et atlas d’endoscopie.
1977;
80-92
Reference Ris Wihthout Link
- 6
Armstrong D, Emde C, Inauen W. et al .
Diagnostic assessment of gastroesophageal reflux disease: what is possible vs. what
is practical?.
Hepatogastroenterology.
1992;
39 Suppl 1
3-13
Reference Ris Wihthout Link
- 7
Lundell L R, Dent J, Bennett J R. et al .
Endoscopic assessment of oesophagitis: clinical and functional correlates and further
validation of the Los Angeles classification.
Gut.
1999;
45
172-180
Reference Ris Wihthout Link
- 8
Labenz J, Nocon M, Lind T. et al .
Prospective follow-up data from the ProGERD study suggest that GERD is not a categorial
disease.
Am J Gastroenterol.
2006;
101
2457-2462
Reference Ris Wihthout Link
- 9
Sharma P, Dent J, Armstrong D. et al .
The development and validation of an endoscopic grading system for Barrett’s esophagus:
the Prague C & M criteria.
Gastroenterology.
2006;
131
1392-1399
Reference Ris Wihthout Link
- 10
Kiesslich R, Kanzler S, Vieth M. et al .
Minimal change esophagitis: prospective comparison of endoscopic and histological
markers between patients with non-erosive reflux disease and normal controls using
magnifying endoscopy.
Dig Dis.
2004;
22
221-227
Reference Ris Wihthout Link
- 11
Yoshikawa I, Yamasaki M, Yamasaki T. et al .
Lugol chromoendoscopy as a diagnostic tool in so-called endoscopy-negative GERD.
Gastrointest Endosc.
2005;
62
698-703
Reference Ris Wihthout Link
- 12
Coenraad M, Masclee A A, Straathof J W. et al .
Is Barrett’s esophagus characterized by more pronounced acid reflux than severe esophagitis?.
Am J Gastroenterol.
1998;
93
1068-1072
Reference Ris Wihthout Link
- 13
Koek G H, Tack J, Sifrim D. et al .
The role of acid and duodenal gastroesophageal reflux in symptomatic GERD.
Am J Gastroenterol.
2001;
96
2033-2040
Reference Ris Wihthout Link
- 14
Masclee A A, Best A C, Graaf de R. et al .
Ambulatory 24-hour pH-metry in the diagnosis of gastroesophageal reflux disease. Determination
of criteria and relation to endoscopy.
Scand J Gastroenterol.
1990;
25
225-230
Reference Ris Wihthout Link
- 15
Smith de J L, Opekun A R, Larkai E. et al .
Sensitivity of the esophageal mucosa to pH in gastroesophageal reflux disease.
Gastroenterology.
1989;
96
683-689
Reference Ris Wihthout Link
- 16
Jamieson J R, Stein H J, DeMeester T R. et al .
Ambulatory 24-h esophageal pH monitoring: normal values, optimal thresholds, specificity,
sensitivity, and reproducibility.
Am J Gastroenterol.
1992;
87
1102-1111
Reference Ris Wihthout Link
- 17
Pehl C, Keller J, Merio R. et al .
Esophageal 24 hour-pH metry. Recommendations of the German Society of Neurogastroenterology
and Motility and the Study Group for Gastrointestinal Functional Disorders and Function
Diagnostics of the Austrian Society of Gastroenterology and Hepatology.
Z Gastroenterol.
2003;
41
545-556
Reference Ris Wihthout Link
- 18
Johnson L F, DeMeester T R.
Development of the 24-hour intraesophageal pH monitoring composite scoring system.
J Clin Gastroenterol.
1986;
8 Suppl 1
52-58
Reference Ris Wihthout Link
- 19
Mainie I, Tutuian R, Castell D O.
Comparison between the combined analysis and the DeMeester Score to predict response
to PPI therapy.
J Clin Gastroenterol.
2006;
40
602-605
Reference Ris Wihthout Link
- 20
Taghavi S A, Ghasedi M, Saberi-Firoozi M. et al .
Symptom association probability and symptom sensitivity index: preferable but still
suboptimal predictors of response to high dose omeprazole.
Gut.
2005;
54
1067-1071
Reference Ris Wihthout Link
- 21
Weusten B L, Roelofs J M, Akkermans L M. et al .
The symptom-association probability: an improved method for symptom analysis of 24-hour
esophageal pH data.
Gastroenterology.
1994;
107
1741-1745
Reference Ris Wihthout Link
- 22
Emde C, Cilluffo T, Bauerfeind P. et al .
Combined esophageal and gastric pH-metry in healthy volunteers. Influence of cable
through LES and effect of misoprostol.
Dig Dis Sci.
1989;
34
79-82
Reference Ris Wihthout Link
- 23
Baldi F, Longanesi A, Ferrarini F.
Esophageal and gastric acidity determination: its value and limitations.
Minerva Chir.
1991;
46
77-81
Reference Ris Wihthout Link
- 24
Jacob P, Kahrilas P J, Herzon G.
Proximal esophageal pH-metry in patients with „reflux laryngitis”.
Gastroenterology.
1991;
100
305-310
Reference Ris Wihthout Link
- 25
Issing W J, Karkos P D, Perreas K. et al .
Dual-probe 24-hour ambulatory pH monitoring for diagnosis of laryngopharyngeal reflux.
J Laryngol Otol.
2004;
118
845-848
Reference Ris Wihthout Link
- 26
Weusten B L, Akkermans L M, vanBerge-Henegouwen G P. et al .
Dynamic characteristic of gastro-oesophageal reflux in ambulatory patients with gastro-oesophageal
reflux disease and normal control subjects.
Scand J Gastroenterol.
1995;
30
731-737
Reference Ris Wihthout Link
- 27
Jung B, Steinbach J, Beaumont C. et al .
Lack of association between esophageal acid sensitivity detected by prolonged pH monitoring
and Bernstein testing.
Am J Gastroenterol.
2004;
99
410-415
Reference Ris Wihthout Link
- 28
Castell D O, Vela M.
Combined multichannel intraluminal impedance and pH-metry: an evolving technique to
measure type and proximal extent of gastroesophageal reflux.
Am J Med.
2001;
111 Suppl 8 A
157S-159S
Reference Ris Wihthout Link
- 29
Tutuian R, Castell D O.
Multichannel intraluminal impedance: general principles and technical issues.
Gastrointest Endosc Clin N Am.
2005;
15
257-264
Reference Ris Wihthout Link
- 30
Silny J.
Intraluminal multiple electric impedance procedure for measurement of gastrointestinal
motility.
J Gastrointest Motil.
1991;
3
151-162
Reference Ris Wihthout Link
- 31
Sifrim D.
Acid, weakly acidic and non-acid gastro-oesophageal reflux: differences, prevalence
and clinical relevance.
Eur J Gastroenterol Hepatol.
2004;
16
823-830
Reference Ris Wihthout Link
- 32
Mainie I, Tutuian R, Shay S. et al .
Acid and non-acid reflux in patients with persistent symptoms despite acid suppressive
therapy: a multicentre study using combined ambulatory impedance-pH monitoring.
Gut.
2006;
55
1398-1402
Reference Ris Wihthout Link
- 33
Tutuian R, Castell D O.
Reflux monitoring: role of combined multichannel intraluminal impedance and pH.
Gastrointest Endosc Clin N Am.
2005;
15
361-371
Reference Ris Wihthout Link
- 34
Castell D O, Mainie I, Tutuian R.
Non-acid gastroesophageal reflux: documenting its relationship to symptoms using multichannel
intraluminal impedance (MII).
Trans Am Clin Climatol Assoc.
2005;
116
321-333; discussion 333 - 324
Reference Ris Wihthout Link
- 35
Tamhankar A P, Peters J H, Portale G. et al .
Omeprazole does not reduce gastroesophageal reflux: new insights using multichannel
intraluminal impedance technology.
J Gastrointest Surg.
2004;
8
890-897 discussion 897 - 898
Reference Ris Wihthout Link
- 36
Dekel R, Martinez-Hawthorne S D, Guillen R J. et al .
Evaluation of symptom index in identifying gastroesophageal reflux disease-related
noncardiac chest pain.
J Clin Gastroenterol.
2004;
38
24-29
Reference Ris Wihthout Link
- 37
Pandolfino J E, Shi G, Zhang Q. et al .
Measuring EGJ opening patterns using high resolution intraluminal impedance.
Neurogastroenterol Motil.
2005;
17
200-206
Reference Ris Wihthout Link
- 38
Zentilin P, Iiritano E, Dulbecco P. et al .
Normal values of 24-h ambulatory intraluminal impedance combined with pH-metry in
subjects eating a Mediterranean diet.
Dig Liver Dis.
2006;
38
226-232
Reference Ris Wihthout Link
- 39
Roman S, Poncet G, Serraj I. et al .
Characterization of reflux events after fundoplication using combined impedance-pH
recording.
Br J Surg.
2007;
94
48-52
Reference Ris Wihthout Link
- 40
Vela M F, Tutuian R, Katz P O. et al .
Baclofen decreases acid and non-acid post-prandial gastro-oesophageal reflux measured
by combined multichannel intraluminal impedance and pH.
Aliment Pharmacol Ther.
2003;
17
243-251
Reference Ris Wihthout Link
- 41
Wong W M, Bautista J, Dekel R. et al .
Feasibility and tolerability of transnasal/per-oral placement of the wireless pH capsule
vs. traditional 24-h oesophageal pH monitoring - a randomized trial.
Aliment Pharmacol Ther.
2005;
21
155-163
Reference Ris Wihthout Link
- 42
Ward E M, Devault K R, Bouras E P. et al .
Successful oesophageal pH monitoring with a catheter-free system.
Aliment Pharmacol Ther.
2004;
19
449-454
Reference Ris Wihthout Link
- 43
Pandolfino J E, Richter J E, Ours T. et al .
Ambulatory esophageal pH monitoring using a wireless system.
Am J Gastroenterol.
2003;
98
740-749
Reference Ris Wihthout Link
- 44
Fass R, Hell R, Sampliner R E. et al .
Effect of ambulatory 24-hour esophageal pH monitoring on reflux-provoking activities.
Dig Dis Sci.
1999;
44
2263-2269
Reference Ris Wihthout Link
- 45
Tu C H, Lee Y C, Wang H P. et al .
Ambulatory esophageal pH monitoring by using a wireless system: a pilot study in Taiwan.
Hepatogastroenterology.
2004;
51
1586-1589
Reference Ris Wihthout Link
- 46
Remes-Troche J M, Ibarra-Palomino J, Carmona-Sanchez R I. et al .
Performance, tolerability, and symptoms related to prolonged pH monitoring using the
Bravo system in Mexico.
Am J Gastroenterol.
2005;
100
2382-2386
Reference Ris Wihthout Link
- 47
des Varannes S B, Mion F, Ducrotte P. et al .
Simultaneous recordings of oesophageal acid exposure with conventional pH monitoring
and a wireless system (Bravo).
Gut.
2005;
54
1682-1686
Reference Ris Wihthout Link
- 48
Ahlawat S K, Novak D J, Williams D C. et al .
Day-to-day variability in acid reflux patterns using the BRAVO pH monitoring system.
J Clin Gastroenterol.
2006;
40
20-24
Reference Ris Wihthout Link
- 49
Triester S L, Leighton J A, Budavari A I. et al .
Severe chest pain from an indwelling Bravo pH probe.
Gastrointest Endosc.
2005;
61
317-319
Reference Ris Wihthout Link
- 50
Fajardo N R, Wise J L, Locke 3 rd G R. et al .
Esophageal perforation after placement of wireless Bravo pH probe.
Gastrointest Endosc.
2006;
63
184-185
Reference Ris Wihthout Link
- 51
Pandolfino J E, Zhang Q, Schreiner M A. et al .
Acid reflux event detection using the Bravo wireless versus the Slimline catheter
pH systems: why are the numbers so different?.
Gut.
2005;
54
1687-1692
Reference Ris Wihthout Link
- 52
Kauer W K, Peters J H, DeMeester T R. et al .
Composition and concentration of bile acid reflux into the esophagus of patients with
gastroesophageal reflux disease.
Surgery.
1997;
122
874-881
Reference Ris Wihthout Link
- 53
Chen X, Yang G, Ding W Y. et al .
An esophagogastroduodenal anastomosis model for esophageal adenocarcinogenesis in
rats and enhancement by iron overload.
Carcinogenesis.
1999;
20
1801-1808
Reference Ris Wihthout Link
- 54
Menges M, Muller M, Zeitz M.
Increased acid and bile reflux in Barrett’s esophagus compared to reflux esophagitis,
and effect of proton pump inhibitor therapy.
Am J Gastroenterol.
2001;
96
331-337
Reference Ris Wihthout Link
- 55
Girelli C M, Cuvello P, Limido E. et al .
Duodenogastric reflux: an update.
Am J Gastroenterol.
1996;
91
648-653
Reference Ris Wihthout Link
- 56
Baldini F, Bechi P, Cianchi F. et al .
Analysis of the optical properties of bile.
J Biomed Opt.
2000;
5
321-329
Reference Ris Wihthout Link
- 57
Vaezi M F, Richter J E.
Duodenogastroesophageal reflux and methods to monitor nonacidic reflux.
Am J Med.
2001;
111 Suppl 8 A
160S-168S
Reference Ris Wihthout Link
- 58
Vaezi M F, Richter J E.
Role of acid and duodenogastroesophageal reflux in gastroesophageal reflux disease.
Gastroenterology.
1996;
111
1192-1199
Reference Ris Wihthout Link
- 59
Vaezi M F, Lacamera R G, Richter J E.
Validation studies of Bilitec 2000: an ambulatory duodenogastric reflux monitoring
system.
Am J Physiol.
1994;
267
G1050-1057
Reference Ris Wihthout Link
- 60
Kauer W K, Burdiles P, Ireland A P. et al .
Does duodenal juice reflux into the esophagus of patients with complicated GERD? Evaluation
of a fiberoptic sensor for bilirubin.
Am J Surg.
1995;
169
98-103
Reference Ris Wihthout Link
- 61
Champion G, Richter J E, Vaezi M F. et al .
Duodenogastroesophageal reflux: relationship to pH and importance in Barrett’s esophagus.
Gastroenterology.
1994;
107
747-754
Reference Ris Wihthout Link
- 62
Caldwell M T, Lawlor P, Byrne P J. et al .
Ambulatory oesophageal bile reflux monitoring in Barrett’s oesophagus.
Br J Surg.
1995;
82
657-660
Reference Ris Wihthout Link
- 63
Bechi P, Pucciani F, Baldini F. et al .
Long-term ambulatory enterogastric reflux monitoring. Validation of a new fiberoptic
technique.
Dig Dis Sci.
1993;
38
1297-1306
Reference Ris Wihthout Link
- 64
Barrett M W, Myers J C, Watson D I. et al .
Detection of bile reflux: in vivo validation of the Bilitec fibreoptic system.
Dis Esophagus.
2000;
13
44-50
Reference Ris Wihthout Link
- 65
Vaezi M F, Singh S, Richter J E.
Role of acid and duodenogastric reflux in esophageal mucosal injury: a review of animal
and human studies.
Gastroenterology.
1995;
108
1897-1907
Reference Ris Wihthout Link
- 66
Byrne J P, Romagnoli R, Bechi P. et al .
Duodenogastric reflux of bile in health: the normal range.
Physiol Meas.
1999;
20
149-158
Reference Ris Wihthout Link
- 67
Sifrim D, Holloway R, Silny J. et al .
Acid, nonacid, and gas reflux in patients with gastroesophageal reflux disease during
ambulatory 24-hour pH-impedance recordings.
Gastroenterology.
2001;
120
1588-1598
Reference Ris Wihthout Link
- 68
Dekel R, Pearson T, Wendel C. et al .
Assessment of oesophageal motor function in patients with dysphagia or chest pain
- the Clinical Outcomes Research Initiative experience.
Aliment Pharmacol Ther.
2003;
18
1083-1089
Reference Ris Wihthout Link
- 69
Lemme E M, Moraes-Filho J P, Domingues G. et al .
Manometric findings of esophageal motor disorders in 240 Brazilian patients with non-cardiac
chest pain.
Dis Esophagus.
2000;
13
117-121
Reference Ris Wihthout Link
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