Int J Sports Med 1988; 09(4): 297-299
DOI: 10.1055/s-2007-1025026
Short Communication

© Georg Thieme Verlag Stuttgart · New York

Satellite Cell Activation in Human Skeletal Muscle After Training: Evidence for Muscle Fiber Neoformation

H.-J. Appell1 , S. Forsberg2 , W. Hollmann2
  • 11nstitute for Experimental Morphology
  • 2Institute for Cardiology and Sports Medicine, German Sports University, Cologne, F. R. Germany
Further Information

Publication History

Publication Date:
14 March 2008 (online)


In subjects who had undergone monopedal bicycle ergometer work for 30 min 4 days a week for 6 weeks under aerobic conditions, biopsies from the M. vastus lateralis were studied in the light and electron microscope. In some cases very small myofibers with central nuclei were found. At the ultrastructural level, these fibers turned out to be myotubes. The satellite cells occasionally appeared to be activated and to fuse with muscle fibers. It was concluded that these observations represented evidence for the development of new muscle fibers.