Int J Sports Med 1990; 11: S37-S46
DOI: 10.1055/s-2007-1024853
© Georg Thieme Verlag Stuttgart · New York

The Purine Nucleotide Cycle Revised

J. M. Lowenstein
  • Graduate Department of Biochemistry, Brandeis University, Waltham, MA 02254, USA
Further Information

Publication History

Publication Date:
14 March 2008 (online)


This review is restricted to the operation of the purine cycle in mammalian muscle. A previous review provided a summary of early evidence for the operation of the cycle and of various functions proposed for the cycle. It also provided a brief history of work on ammonia production by muscle and other tissues and of the discovery of the enzymes of the purine nucleotide cycle (36). Recent reviews on the purine nucleotide cycle include those of Terjung et al. (78) and van Waarde (86).