Int J Sports Med 1991; 12(2): 187-189
DOI: 10.1055/s-2007-1024665
© Georg Thieme Verlag Stuttgart · New York

Effect of Prolonged Exercise on Insulin Level in the Portal and Peripheral Venous Circulation in Rats

S. Cardin, B. Doiron, J.-M. Lavoie
  • Départment d'éducation physique Université de Montréal
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Publication History

Publication Date:
14 March 2008 (online)


The purpose of the present study was to compare the plasma insulin levels in portal and peripheral veins in rats submitted to a prolonged exercise to exhaustion (x̄±SE: 67 ± 7 min). Plasma insulin levels were reduced significantly (p < 0.01) during exercise in both the portal and peripheral venous circulation. The reduction was, however, more pronounced in the portal than in the peripheral vein(x̄: - 113 vs - 64 and - 162 vs - 88 pmol·1-1 after 30 and 45 min of exercise, respectively), indicating that exercise reduced not only insulin secretion but also its removal. Accordingly, no significant differences were found for the portal/peripheral ratio of insulin at rest and during the first 45 min of exercise (1.86±0.2, 1.76±0.1, and 1.57±0.2 at rest, and after 30 and 45 min of exercise, respectively). This suggests that insulin removal during exercise is regulated in proportion to portal insulin concentrations.