Int J Sports Med 1992; 13(4): 308-312
DOI: 10.1055/s-2007-1021272
© Georg Thieme Verlag Stuttgart · New York

Effects of Captopril Chronic Intake on the Aerobic Performance and Muscle Strength of Normotensive Trained Subjects

F. Carré1 , R. Handschuh2 , J. Beillot1 , J. Dassonville1 , P. Rochcongar1 , P.-H. Guivarc'h3 , Y. Lessard1
  • 1Service d'Explorations Fonctionnelles et Médecine du Sport, Pr. R. Le Bars, Hopital Pontchaillou, 35033 Rennes, France
  • 2Hopital Pean, 75013 Paris, France
  • 3Laboratoires Squibb, La Defense, Paris, France
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Publication History

Publication Date:
14 March 2008 (online)


Fifteen normotensive athletes specializing in dynamic sports took part in a randomized double-blind and cross-over study: Captopril (50 mg/24 h) vs placebo. Each treatment lasted one month. Maximal exercise tests on cycle ergometer were performed at the end of each period. No significant differences were observed in the maximal values of oxygen uptake, power, heart rate or blood lactate value. The anaerobic threshold, defmed as the exercise intensity which corresponded to a 4 mmol·l-1 blood lactate level was unchanged. With captopril, the end-of-exercise systolic and diastolic BP were slightly altered (NS). Lower limb muscle strength, as explored with a Cybex isokinetic System, was not modified by captopril intake. The results indicate that maximal aerobic Performance and isokinetic strength of the lower limbs are not altered by captopril chronic administration (50 mg/day) in normotensive trained subjects.