Int J Sports Med 1992; 13(4): 293-297
DOI: 10.1055/s-2007-1021269
© Georg Thieme Verlag Stuttgart · New York

Depressed Systolic and Diastolic Cardiac Function after Prolonged Aerobic Exercise in Healthy Subjects

R. Ketelhut, C. J. Losem, F. H. Messerli
  • Department of Internal Medicine, Section on Hypertensive Diseases, Ochsner Clinic and Alton Ochsner Medical Foundation, New Orleans, Louisiana, USA
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Publication History

Publication Date:
14 March 2008 (online)


We studied 11 healthy untrained volunteers (aged 28.9±4.6 years) during 60 minutes of aerobic ergometric exercise with constant heart rates of 130 to 140 beats/minute. We found a continuous and significant decrease in systolic and diastolic pressure from 175±18/77±7 mmHg in the 5th minute to 144±14/68±6 mmHg in the 60th minute of exercise. Cardiac function and structure were assessed by M-mode echocardiography before exercise, after 5 minutes and after 60 minutes of exercise at comparable heart rates. The results demonstrated significant decreases in cardiac Output, ejection fraction, and diastolic posterior wall velocity and an increase in total peripheral resistance after 60 minutes of exercise. We conclude that the decrease in blood pressure during long-term aerobic exercise in healthy untrained subjects might be at least influenced by a decrease in left ventricular filling and contractility, possibly indicating cardiac fatigue.