Reduction of Thrombogenicity in Small-diameter Vascular Prostheses Seeded with Autologous Endothelial Cells

G. B. Köveker; K. H. Petzke; M. Borg; K. Nebendahl

doi:10.1055/s-2007-1020372

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Thorac Cardiovasc Surg 1986; 34(1): 49-51
DOI: 10.1055/s-2007-1020372

Reduction of Thrombogenicity in Small-diameter Vascular Prostheses Seeded with Autologous Endothelial Cells

G. B. Köveker, K. H. Petzke, M. Borg, K. Nebendahl

Department of Surgery, University of Göttingen, FRG

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Publication History

Publication Date:
19 March 2008 (online)

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Summary

In a canine model small-diameter vascular grafts of knitted Dacron were seeded with autologous endothelial cells. Four weeks after surgery the grafts were removed. Seeded grafts showed a pseudo-intima covered by a monolayer, whereas control grafts showed a cellular lining only at the anastomoses. Graft pretreatment with either fibrin glue or autologous blood in combination with endothelial cell seeding promoted the neointima formation.

Key words

Vascular prostheses - Endothelial cell seeding - Fibrin glue

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