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Horm Metab Res 1981; 13(12): 696-699
DOI: 10.1055/s-2007-1019379
© Georg Thieme Verlag, Stuttgart · New York

Intermittent Stimulation with LH-RH in Postmenopausal Hypergonadotropism

J. P. Hanker, U. Ende, H. G. Bohnet, H. P. G. Schneider
  • Frauenklinik der Westfälischen Wilhelm-Universität, Münster, Germany
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Publication History

1980

1981

Publication Date:
14 March 2008 (online)

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Summary

Ten postmenopausal women received 8 consecutive (1 hour interval ) i.v. bolus injections of either 25 or 500 μg of LH-RH. Gonadotropin release was monitored before and during LH-RH stimulation.

After the first LH-RH bolus a dose-dependent LH release was seen. All consecutive LH-RH boli elicited similar LH responses resulting in pulse-type LH release.

Throughout the whole stimulation period the pituitary gland remained highly responsive to LH-RH. FSH release was uncharacteristic.

It is concluded that during postmenopause LH-RH is hypersecreted. Thus the pituitary gland remains responsive to repeated injections of even supraphysiological LH-RH doses.

Key-Words:

Intermittent LH-RH Stimulation - LH-RH - Postmenopausal Hypergonadotropism

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