The role of prolactin as a diabetogenic hormone is still controversial. The present
study examines intravenous glucose tolerance in six subjects with prolactin secreting
pituitary adenomas. Testing was performed in each individual both in the untreated
high prolactin state and again after prolactin was reduced by bromocriptine treatment
for three months. Lowering serum prolactin failed to improve intravenous glucose tolerance
or alter insulin release. It is concluded that prolactin has no significant effect
on glucose disposal.
Glucose Tolerance
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Prolactin
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Insulin
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Bromocriptine
