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DOI: 10.1055/s-2007-1019340
Effects of Thyroid Hormone and Adrenalectomy on [Na+ + K+]ATPase in the ob/ob Mouse
Publication History
1980
1981
Publication Date:
14 March 2008 (online)
Summary
The absence of the thyroid stimulation of hepatic [Na+ + K+]ATPase in obese (ob/ob) mice has been investigated. A wide range of tri-iodothyronine (T3) concentrations failed to enhance the hepatic [Na+ + K+]ATPase of ob/ob mice made hypothyroid by methimazole treatment but glycero-phosphate dehydrogenase activity was maximally stimulated at low doses of T3. Adrenalectomy increased the basal activity of [Na+ + K+]ATPase to levels found in lean control mice and restored the response of this enzyme to T3. Body weight gain was unaffected by the induction of hypothyroidism in either lean or ob/ob mice. It is concluded that the adrenal steroids play an important role in the expression of [Na+ + K+]ATPase activity in the ob/ob mouse.
Key-Words:
Tri-Iodothyronine - Glycerophosphate Dehydrogenase - Hypothyroidism - Body Weight