Horm Metab Res 1981; 13(9): 480-483
DOI: 10.1055/s-2007-1019311
© Georg Thieme Verlag, Stuttgart · New York

Effect of Anti-Insulin Receptor Antibody on Insulin Dissociation from IM-9 Lymphocytes

W. G. Blackard, C. H. Ludeman
  • Department of Medicine, Medical College of Virginia, Richmond, Virginia, U.S.A.
Further Information

Publication History

1980

1980

Publication Date:
14 March 2008 (online)

Summary

Although anti-insulin receptor antibodies mimic insulin in many of its actions, antireceptor antibodies in serum from a diabetic patient did not share the property of insulin to produce negative cooperativity as defined by the DeMeyts experiment. In contrast, an inhibition of insulin dissociation from IM-9 lymphoblastoid cells was observed after exposure to the antireceptor antibody. The capacity of this particular antireceptor antibody to attach to cells whose insulin receptors have been saturated suggests that the antibody may trap insulin by molecular hindrance.