Turnover Rate of Blood Glucose in Diabetic KK Mice

Summary

Metabolic rate constants for blood glucose turnover were estimated based on the decay of [U-¹⁴C, 6-³H]glucose injected intravenously in genetically diabetic KK mice. Comparison was made with the rate constants similarly obtained with non-diabetic and streptozotocin-induced diabetic ICR mice. Recycling of blood glucose via the Cori cycle, as estimated from the difference in the decay rate between ¹⁴C and ³H, was more active in KK mice than in non-diabetic and diabetic ICR mice. The Cori cycle activity was reduced by β-adrenergic blockade in KK mice and was enhanced by α-blockade in ICR mice. It is concluded that predominance of β-adrenergic functions in KK mice is responsible for activation of the Cori cycle as one of the mechanisms for metabolic resistance to endogenous insulin.

Key-Words:

KK Mice - Streptozotocin-Induced Diabetic Mice - Blood Glucose Turnover - Cori Cycle Activity - α-Adrenergic Antagonist - β-Adrenergic Antagonist