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Horm Metab Res 1981; 13(5): 282-284
DOI: 10.1055/s-2007-1019244
© Georg Thieme Verlag, Stuttgart · New York

The Effect of Acute Hypercalcemia on Prolactin Release in Man

K. Ajlouni, M. El Khateeb
  • Departments of Internal Medicine and Clinical Pathology, University of Jordan, Faculty of Medicine, Amman, Jordan
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Publication History

1980

1980

Publication Date:
23 April 2008 (online)

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Summary

The serum prolactin response to acute hypercalcemia during calcium infusion was studied in 7 normal subjects. Prolactin, and calcium levels were determined at 30 minute intervals during the 210 minutes of the infusion. The infusions performed consisted of either normal saline at 3 ml/min for 210 minutes, or 15 mg calcium/kg at 3 ml/min for 180 minutes followed by normal saline infusion for the final 30 minutes. Calcium concentration increased from a base line of 10.1 ± 0.26 (mean ± SEM) to a maximal level of 13.6 ± 0.26 (mean ± SEM) mg/100 ml, in response to calcium levelin response to normal saline infusion. Prolactin level decreased significantly (P < 0.05) from 9.5 ± 1.45 (mean ± SEM) to 3.7 ± 0.2 (mean ± SEM) ng/ml at 180 minutes.

These results suggest that acute hypercalcemia decreases the prolactin level suggesting some relation between calcium concentration and prolactin release.

Key-Words:

Calcium - Prolactin