Horm Metab Res 1981; 13(5): 267-272
DOI: 10.1055/s-2007-1019241
© Georg Thieme Verlag, Stuttgart · New York

Short Term Regulation of Mouse Pyruvate Dehydrogenase Complex by Insulin

M. Imura, O. Takatani
  • 3rd Internal Medicine, National Defence Medical College, Tokorozawa, Japan
Further Information

Publication History

1979

1980

Publication Date:
23 April 2008 (online)

Summary

Pyruvate dehydrogenase complex activity and its regulating factors were measured in diabetic mice in a starved or unstarved state. Both in starved and unstarved groups of normal mice, pyruvate dehydrogenase complex activity increased equally by insulin administration. On the other hand, in an unstarved group of diabetic mice, no change in pyruvate dehydrogenase complex activity was observed with the same treatment. With the starved group it increased within 10 minutes and recovered to the base value level in 30 minutes. As a result of studies on active form of pyruvate dehydrogenase complex in the liver and its regulating factors, it was found that no corresponding relation existed between the enzyme complex activity and its regulating factors. We found that unlike the normal mice, not only the previously known regulating mechanism but also other factors affected the pyruvate dehydrogenase complex activity in the diabetic mice.