Summary
Aryl hydrocarbon hydroxylase (AHH) and 7-ethoxycoumarin O-deethylase (ECD) activities
of microsomes from liver, lung, and intestine of control and adrenalectomized male
and female rats were compared. In addition, adrenalectomized-ovariectomized rats were
also used. Adrenalectomy decreased hepatic and pulmonary AHH and ECD activities in
microsomes of both sexes. However, adrenalectomy increased the AHH activity of intestinal
microsomes of both male and female rats, but had no effect on the intestinal ECD activity
of either sex. The hepatic cytochrome P-450 content was decreased in male and female
animals by adrenalectomy. The effects of adrenalectomy-ovariectomy on AHH and ECD
activities were similar to the results obtained for adrenalectomy alone, indicating
that physiological levels of estrogens do not regulate these enzymes. Organ specific
alterations of microsomal mixed function oxidases occur with adrenalectomy of both
male and female rats.
Key-Words:
Aryl Hydrocarbon Hydroxylase (AHH)
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7-Ethoxycoumarin O-Deethylase (ECD)
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Cytochrome P-450
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Adrenalectomy
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Adrenalectomy-Ovariectomy
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Hepatic
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Extrahepatic
