Summary
Studies were carried out on the production of the glucuronide hormone glomerulopressin
by the isolated rat liver in male and female rats, and the effect on this production
of an inhibitor (Novobiocin) and a stimulator (benzo-(a)pyrene) of glucuronyltransferase
activity.
It was observed that males produce more glomerulopressin than females, Novobiocin
inhibits its production while benzo-(a)pyrene enhances it in females but not in males.
The changes in glomerulopressin production are related to the changes in glucuronyltransferase
activity observed by other authors, suggesting that this enzyme is involved in the
production of glomerulopressin.
Key-Words:
Glomerulopressin
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Glucuronides
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Liver
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Novobiocin
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Benzo(a)Pyrene
