During phagocytosis, polymorphonuclear leukocytes from poorly controlled diabetic
patients convert lysolecithin to lecithin at a lower rate than cells from control
subjects. This defect is partially reversed by treatment with insulin. By reducing
the availability of structural lipid for formation of the phagocytic vacuole which
normally takes place during phagocytosis, this impairment may compromise cellular
hostdefense mechanisms in some diabetic patients.
Phagocytosis
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Diabetic Leukocytes
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Lecithin Synthesis
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Lysolecithin Acylation
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Membrane Synthesis
