Reduced 3H-Dopamine Uptake by Blood Platelets in Patients with Prolactin-Secreting Pituitary Adenoma

I. Nicoletti; E. Capodicasa; F. Santeusanio; G. G. Nenci; P. Brunetti

doi:10.1055/s-2007-1019002

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Horm Metab Res 1982; 14(6): 310-312
DOI: 10.1055/s-2007-1019002

Reduced ³H-Dopamine Uptake by Blood Platelets in Patients with Prolactin-Secreting Pituitary Adenoma

I. Nicoletti, E. Capodicasa, F. Santeusanio, G. G. Nenci, P. Brunetti

Istituti di Clinica Medica, Semeiotica Medica e Patologia Medica, University of Perugia, Perugia, Italy

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Publication History

1981

1981

Publication Date:
23 April 2008 (online)

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Summary

Uptake of ³H-Dopamine by blood platelets was found to be significantly reduced in eight patients with prolactin (PRL) secreting pituitary adenoma in comparison to normal subjects (27.91±5.01 nmol/10¹¹ platelets vs. 73.42±4.99 nmol/10¹¹ platelets, p<0.001). Since platelet monoamine uptake seems to reflect brain monoaminergic activity, the reduction of dopamine uptake (DAU) in our hyperprolactinemic subjects suggests a defective dopaminergic neurotransmission in patients with PRL-secreting tumors.

Key-Words:

³ H-Dopamine Uptake - PRL-Secreting Adenoma - Blood Platelets