Summary
The administration of haloperidol increased serum prolactin and decreased the pituitary
concentration of prolactin 15 min after its administration. Concomitantly there was
a stimulation in the synthesis of DNA and the activity of DNA polymerase α in the
anterior pituitary gland that was greater in oestrogenized than in non-oestrogenized
male rats. Both these effects were greatly reduced by clomiphene in the oestrogenized
male rats, although it did not affect the release of prolactin produced by haloperidol.
In non-oestrogenized animals clomiphene abolished the stimulatory effect of haloperidol
on the synthesis of DNA.
These results suggest that the reduction in the intracellular levels of prolactin
are a primary event in the oestrogen mediated stimulation of cell proliferation by
prolactin releasing agents.
Key-Words:
Pituitary Gland
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DNA Synthesis
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Oestrogens
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Haloperidol
