Plasma Glucose and Insulin Responses to Glucagon and Arginine in Aston ob/ob Mice: Evidence for a Selective Defect in Glucose-Mediated Insulin Release

P. R. Flatt; C. J. Bailey

doi:10.1055/s-2007-1018945

Hormone and Metabolic Research, Inhaltsverzeichnis

Horm Metab Res 1982; 14(3): 127-130
DOI: 10.1055/s-2007-1018945

Plasma Glucose and Insulin Responses to Glucagon and Arginine in Aston ob/ob Mice: Evidence for a Selective Defect in Glucose-Mediated Insulin Release

P. R. Flatt, C. J. Bailey

Department of Biochemistry, University of Surrey, Guildford, Surrey; Department of Biological Sciences, University of Aston in Birmingham, Birmingham, United Kingdom

Abstract

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Summary

Fed adult obese hyperglycaemic (ob/ob) mice fail to produce a positive plasma insulin response to an intraperitoneal (ip) glucose challenge. The present study demonstrates that both fed and fasted ob/ob mice produce a marked positive plasma insulin response to an ip challenge by glucagon or arginine throughout the phases of development and regression of the ob/ob syndrome. These observations provide evidence that failure of the B-cells to respond to glucose in fed adult ob/ob mice cannot be attributed to inadequate amounts of releasable insulin. In addition, the results show that the B-cells of fed adult ob/ob mice do not incur a generalized defect of stimulus-recognition-secretion-coupling.

Key-Words:

Arginine - Glucagon - Obese Hyperglycaemic (ob/ob) Mice

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