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Horm Metab Res 1982; 14(2): 94-97
DOI: 10.1055/s-2007-1018933
© Georg Thieme Verlag, Stuttgart · New York

Effects of 2-Deoxy-D-Glucose on Plasma and Adrenal Concentrations of Corticosterone and Aldosterone in Standard Diet Fed and Potassium Loaded Rats

C. Chevrier, N. Hammiche, R. Brudieux1
  • Laboratoire d'Endocrinologie et Ecophysiologie Animale, Centre National de Recherches sur les Zones Arides (O.N.R.S.), Faculté des Sciences, Algérie
  • 1Laboratoire d'Endocrinologie Comparée, Département d'Endocrinologie, U.E.R. de Biologie, Université de Bordeaux I, Talence, France
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Publication History

1980

1981

Publication Date:
14 March 2008 (online)

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Summary

The concentrations of corticosterone, aldosterone and electrolytes (Na+ and K+) were measured in the plasma and adrenal glands, following 2-deoxy-D-glucose (2-DG) treatment (2 injections of 50 mg/ml/100 g body weight) in standard diet fed and potassium loaded rats.

In both regimes, 2-DG increased the concentrations of corticosterone mainly in the plasma (+144.8 % and 229.5 %) and to a lesser extent, in the adrenal glands (+50.9 % and 62.5 %).

Conversely, 2-DG treatment was followed by a steep decline in plasma concentrations of aldosterone both in standard diet fed rats (-65.2 %) and in potassium loaded rats (-83.9 %), in spite of a marked increase in plasma (+233.3 %) and in adrenal (+54.9 %) levels of aldosterone after potassium loading; adrenal aldosterone content was essentially the same.

Plasma and adrenal electrolytes concentrations and hematocrit varied very little after 2-DG treatment.

Key-Words:

2-Deoxy-D-Glucose - Corticosterone - Aldosterone - Rat

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