Summary
The activity of pyruvate dehydrogenase complex was measured in skeletal muscle of
congenital diabetic mice (KK mice) and control mice (ddN mice), each group in a starved or unstarved state, with or without muscular contraction.
The age related increment of the level of active form pyruvate dehydrogenase complex
in KK mice was not found compared with that in ddN mice. In 4 weeks old KK mice, the
increment of the active form by muscular contraction or the decrease by 48 hours starvation
was not different from the control mice. On the other hand, in 12 week old KK mice,
the changes of the enzyme activity by muscular contraction were different from the
normal control.
These results suggest that the activity of pyruvate dehydrogenase complex is intimately
related to the onset of diabetes.
Key-Words:
Pyruvate Dehydrogenase Complex
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KK Mice
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Skeletal Muscle
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Muscular Contraction
