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Horm Metab Res 1983; 15(8): 370-372
DOI: 10.1055/s-2007-1018727
© Georg Thieme Verlag, Stuttgart · New York

Effects of Insulin on Thyrotropin Releasing Hormone from Frog Skin

T. Mitsuma, T. Nogimori
  • Fourth Department of Internal Medicine, Aichi Medical University, Nagakute, Aichi, Japan
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Publication History

1982

1982

Publication Date:
14 March 2008 (online)

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Summary

Thyrotropin releasing hormone (TRH) is concentrated in the skin of Rana nigromacula. Its elution profile on Sephadex G-10 was identical to that of synthetic TRH. Insulin and noradrenaline stimulated TRH release from frog skin in a dose-related manner. The effects of insulin were not blocked by preincubation with phentolamine and they enhanced the noradrenaline effect. These data indicate that insulin stimulates directly TRH release from frog skin in other than the sympathetic pathway.

Key-Words:

Thyrotropin Releasing Hormone - Frog Skin - Insulin - Noradrenaline