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Horm Metab Res 1983; 15(3): 120-123
DOI: 10.1055/s-2007-1018647
© Georg Thieme Verlag, Stuttgart · New York

Glucose Tolerance in Aging Obese (ob/ob) and Lean Mice

P. U. Dubuc, S. Ristimaki, P. J. Cahn, P. L. Willis
  • Department of Metabolism and Endocrinology, City of Hope National Medical Center, Duarte, California, U.S.A.
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Publication History

1981

1982

Publication Date:
14 March 2008 (online)

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Summary

Examination of the glucose tolerance in younger (3 month) and older (6 month) obese mice revealed that most of their postinjection hyperglycemia arises from the disproportionately large glucose responses to the injection/bleeding procedures rather than from the added glucose. Simultaneous measurements of circulating glucagon, corticosterone and insulin indicated that simple differences in the levels of these hormones, in their circulating ratios, or in the magnitude of the hormone responses to stimulation did not fully account for the “stress”-induced hyperglycemia.

Key-Words:

ob/ob Mice - Glucose Intolerance - Glucagon - Insulin - Corticosterone - Starvation - Aging

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