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Endoscopy 1983; 15(1): 4-7
DOI: 10.1055/s-2007-1018595
© Georg Thieme Verlag KG Stuttgart · New York

A Study of the Mechanism of the Toluidine Blue Dye Test

P. Herlin* , J. Marnay* , J.H. Jacob** , J.M. Ollivier*** , A.M. Mandard****
  • *Department of Pathology - Centre Régional François Baclesse - 14021 Caen Cedex, France
  • **Department of Digestive Endoscopy - Centre Régional François Baclesse -
  • ***Department of Surgery - Centre Régional François Baclesse -
  • ****Department of Pathology (Electron Microscopy) - Centre Hospitalier Universitaire and Centre Regional François Baclesse
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Publication Date:
17 March 2008 (online)

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Summary

Toluidine blue is commonly used by endoscopists as a screening test for squamous cell carcinoma. Little information is available on the mechanism of vital staining as it is not preserved by conventional fixation. By using a simple method to stabilize toluidine blue, the authors were able to study the action of the dye under the light and electron microscope. The findings are reported.

Key words:

Vital staining - Toluidine blue dye test - Cancer screening - Light and electron microscopy