Summary
Upper gastrointestinal endoscopy revealed gastroduodenal polyps in 45 (90 %) out of
50 patients with familial adenomatosis (FA), and in 11 (92 %) out of 12 patients with
juvenile polyposis (JP). The polyps in the fundic and corpus regions of the stomach
were hamartomatous cystic body gland polyps in 28 (56 %), and adenomas in 3 (6 %)
of the FA patients, while 6 (50 %) JP patients had hyperplastic polyps in the corresponding
region. The polyps in the gastric antrum and duodenum were adenomas in 6 (12 %) and
25 (50 %) of the FA patients, respectively, while the polyps of the corresponding
regions were hyperplastic in 10 (83 %) and 2 (17 %) of the JP subjects. One focal
adenomatous lesion in an antral hyperplastic polyp, and one duodenal adenoma were
found in the JP patients. Furthermore, one duodenal adenocarcinoma was observed among
the FA subjects. It is concluded that gastroduodenal polyps belong inherently both
to adenomatous and to juvenile varieties of gastrointestinal polyposis, and that these
two conditions have characteristic histological patterns and topography of polyps
in the upper gastrointestinal tract.
Key words:
Familial adenomatous polyposis - Juvenile polyposis - Upper gastrointestinal polyps
- Gastroduodenoscopy
