Zusammenfassung
Der gegenwärtig zu beobachtende Anstieg an Verschreibungen von Disulfiram setzt ärztliche
Kenntnisse bezüglich Pharmakodynamik, -kinetik, Nebenwirkung und Wechselwirkung der
Substanz voraus. Wir geben eine Übersicht über die Pharmakologie und unerwünschte
Nebenwirkungen der Substanz Disulfiram. Beispielhaft wird ein Fall vorgestellt, bei
welchem ein akutes neurologisches Defizit zunächst als Nebenwirkung von Disulfiram
verkannt wurde. Diskutiert werden mögliche Perspektiven von Disulfiram in der Suchtmedizin.
Abstract
Recently, we have been observing an increase in prescription of Disulfiram requiring
medical knowledge concerning the overall effects, side effects and drug interactions
of this substance. In the following report, we give an overview about the pharmacology
and the side effects of Disulfiram. As an example we demonstrate a case, in which
an acute neurological deficit was misjudged as a side effect of Disulfiram. Furthermore,
the potential of Disulfiram as a promising treatment in addiction medicine will be
discussed.
Schlüsselwörter
Disulfiram - Alkohol - Nebenwirkungen - Wechselwirkungen - Arzneimittel-Interaktionen
Key words
Disulfiram - alcohol - side effects - adverse drug reactions - drug interactions
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1
Interessenkonflikt. Es besteht kein Interessenkonflikt. Die Autoren versichern, dass keine Verbindungen
mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein
Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig
und die Darstellung der Inhalte produktneutral.
Dr. med. Alexander Diehl
Klinik für Abhängiges Verhalten und Suchtmedizin, Ärztlicher Direktor Prof. Dr. Karl
Mann, Zentralinstitut für Seelische Gesundheit
Quadrat J 5
68159 Mannheim
Email: alexander.diehl@zi-mannheim.de