During regeneration of rat livers following 70% hepatectomy, insulin binding sites
on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites
are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly
increased. An apparent paradox was the finding of a depression of the activity of
an insulin associated enzyme, glucokinase, at a time when the number of insulin binding
sites was increased.
Glucokinase
-
Insulin Glucagon Receptors
-
Liver Regeneration
-
Rat
