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Horm Metab Res 1984; 16: 47-50
DOI: 10.1055/s-2007-1014896
© Georg Thieme Verlag, Stuttgart · New York

Discordance between Glucokinase Activity and Insulin and Glucagon Receptor Changes Occurring during Liver Regeneration in the Rat

A. Francavilla1 , A. Di Leo1 , S. Q. Wu2 , P. Ove3 , D. Van Thiel4 , C. Sciascia5 , T. E. Starzl2
  • 1Department of Gastroenterology, University of Bari, Bari, Italy
  • 2Department of Surgery, School of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.
  • 3Department of Anatomy, School of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.
  • 4Department of Gastroenterology, School of Medicine, University of Pittsburgh, Pittsburgh, PA, U.S.A.
  • 5Department of Surgery, University of Torino, Torino, Italy
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1983

1984

Publikationsdatum:
23. April 2008 (online)

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Summary

During regeneration of rat livers following 70% hepatectomy, insulin binding sites on hepatocyte plasma membranes are increased after 24-48 hours, glucagon binding sites are reduced on days 2-8, and the resultant insulin/glucagon binding ratio is markedly increased. An apparent paradox was the finding of a depression of the activity of an insulin associated enzyme, glucokinase, at a time when the number of insulin binding sites was increased.

Key-Words:

Glucokinase - Insulin Glucagon Receptors - Liver Regeneration - Rat