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Horm Metab Res 1984; 16(9): 465-467
DOI: 10.1055/s-2007-1014820
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© Georg Thieme Verlag, Stuttgart · New York

Role of Protein Kinase and Contractile Force in the Regulation of Myocardial Lipolysis

R. A. Rabin, D. O. Allen
  • Department of Pharmacology, University of South Carolina, School of Medicine, Columbia, South Carolina, U.S.A.
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Publication History

1983

1983

Publication Date:
14 March 2008 (online)

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Summary

The time and dose-relationships of isoproterenol and lipolysis, force of contraction, cyclic AMP levels, protein kinase activity and phosphorylase activity were studied in perfused rat hearts. All five parameters were increased by isoproterenol over very similar concentration ranges. Dibutyryl cyclic AMP also increased phosphorylase activity, force of contraction and lipolysis. The study supports a role for cyclic AMP and protein kinase in myocardial lipolysis but suggests that a cyclic AMP-independent mechanism also exists.

Key-Words:

Protein Kinase - Lipolysis - Cyclic AMP - Heart - Phosphorylase