Horm Metab Res 1984; 16(6): 286-289
DOI: 10.1055/s-2007-1014770
© Georg Thieme Verlag, Stuttgart · New York

The Effect of Exogenous Growth Hormone on Insulin Requirements during Closed Loop Insulin Delivery in Insulin-Dependent Diabetes Mellitus

G. M. Bright, R. W. Melton, A. D. Rogol, W. L. Clarke
  • Division of Endocrinology and Diabetes and Clinical Pharmacology, Department of Pediatrics and the Diabetes Research and Training Center, University of Virginia Medical Center, Charlottesville, Virginia, U.S.A.
Weitere Informationen

Publikationsverlauf

1982

1983

Publikationsdatum:
14. März 2008 (online)

Preview

Summary

The amount of insulin required to maintain similar blood glucose concentrations during an eight hour infusion of either saline or growth hormone (2 μg/kg/hr) was determined in five fed, insulin-dependent diabetic subjects during closed-loop insulin delivery. Elevations of serum growth hormone concentrations to levels previously observed in poorly controlled diabetic subjects were not accompanied by differences in the amount of insulin required to maintain blood glucose concentrations at levels comparable to those observed during the saline infusion. Specifically, no early insulin-like nor late anti-insulin effects of physiologic increases in serum growth hormone concentrations (10.27 ± 0.23 mg/ml vs 5.69 ± 1.5 mg/ml, P < 0.05) on mean hourly blood glucose levels or mean hourly insulin requirements were observed. These studies suggest that serum growth hormone concentrations similar to those observed in poorly controlled diabetics do not affect the insulin requirements of well-insulinized diabetic subjects.