Horm Metab Res 1984; 16(4): 201-203
DOI: 10.1055/s-2007-1014742
© Georg Thieme Verlag, Stuttgart · New York

In Vivo Effect of Progesteron and Estrogen on Thymus Mass and T-Cell Functions in Female Mice

T. Marotti, M. Sirotković, J. Pavelić, J. Gabrilovac, K. Pavelić
  • Ruder Bošković Institute, Department of Experimental Biology and Medicine, Zagreb, Yugoslavia
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Publication Date:
14 March 2008 (online)


Progesteron and estradiol, administered in doses equivalent to those used for therapy caused a marked transient reduction of the thymus mass, but did not affect the cellularity of other lymphoid organs. Humoral and cellular immune response of the hormone-treated mice was normal at the time of thymus involution. The same was true for the stem-cell differentiation capacity. The remaining thymus cells after hormone treatment showed increased DNA-synthesis.