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Horm Metab Res 1984; 16(2): 67-70
DOI: 10.1055/s-2007-1014699
© Georg Thieme Verlag, Stuttgart · New York

Lipoprotein Lipase Activities in Heart Muscle of Streptozotocin-Induced Diabetic Rats

T. Nakai, K. Oida, T. Tamai, S. Yamada1 , T. Kobayashi, T. Hayashi, Y. Kutsumi, R. Takeda
  • Second Department of Internal Medicine, School of Medicine, Kanazawa University, Kanazawa City, Japan
  • 1Department of Internal Medicine, Cancer Research Institute, Kanazawa University, Kanazawa City, Japan
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Publikationsverlauf

1982

1983

Publikationsdatum:
14. März 2008 (online)

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Summary

Triglyceride lipase (TGL) activities in the homogenates of the rat heart muscle were studied. TGL activity per mg protein of heart muscle was the highest in heart muscle homogenate utilizing 2.1 M glycine buffer, pH 8.3 among the assays investigated. The effects of NaCl, serum and heparin on TGL activities in heart muscle homogenates indicated the characteristics of lipoprotein lipase (LPL). Twelve-hour fasting increased heart muscle LPL activity, while enzyme activities in 48 hour- and 72 hour-fasted rats were lower than those in fed rats. LPL activities in heart muscle homogenates in streptozotocin (STZ)-induced diabetic rats either 3 days or 4 weeks after STZ injection, were decreased significantly as compared with those of control rats.

Key-Words:

Lipoprotein Lipase - Heart Muscle - Diabetes Mellitus - Lipoprotein - Insulin - Rat